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In the early stages of avascular necrosis, some people have no symptoms. However, as the condition worsens, the affected joints may only hurt when you put weight on them, and the pain may eventually be felt even when lying down.
The pain can range from mild to severe and usually takes time to develop. Avascular necrosis of the hip can cause pain in the groin, thigh, or buttock. In addition to the hip, the shoulder, knee, hand, and foot may also be affected. Avascular necrosis can occur on both sides, such as in both hips or both knees. |
The following are the most common symptoms of avascular necrosis. However, each person may experience symptoms differently. Symptoms may include:
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Causes |
Explanation |
Joint or bone trauma |
An injury, such as a dislocated joint, might damage nearby blood vessels. Cancer treatments involving radiation also can weaken bone and harm blood vessels. |
Fatty deposits in blood vessels |
The fat (lipids) can block small blood vessels. This can reduce blood flow to bones. |
Certain diseases |
Medical conditions, such as sickle cell anemia and Gaucher's disease, also can lessen blood flow to bone. |
Medications In the early stages of avascular necrosis, certain medications may help ease symptoms. The type of Medication may help Ease Symptoms:
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Therapy Your health care provider might recommend you to do :
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Surgical and Other Procedures Web Because most people don't develop symptoms until avascular necrosis is advanced, your healthcare provider might recommend surgery. For example:
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CelltiMax is Mesenchymal Stem Cells (MSCs) derived from human umbilical cords. Upon treatment, the cultured cells are injected intramuscularly / intravenously into the patient.
The cells are characterized by low immunogenicity. Hence, it is very safe, tolerable, and free of side effects. It has the capability to differentiate into specialized cells with specific functions for many parts of the body. They can reduce inflammation, repair, renew, regenerate, and replace damaged cells. |
CRITERIAS |
STEM CELLS |
EXOSOMES |
Definition |
Stem cells are unspecialized cells of the human body |
Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells |
Function |
Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body |
Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells |
Origins |
Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells |
Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized |
Growth Factors |
Less amount of growth factors compared to exosomes |
Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells |
Administration |
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Value |
High stabililty |
Low toxicity and immunogenicity |
High penetration |
Enhanced delivery efficiency |
MSC clinical applications Avascular necrosis
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MSCs have clinical applications for treating avascular necrosis of the hip. Avascular necrosis of the hip is a pathological condition caused by a disruption in blood supply to the femoral head. MSCs can be used to supplement the core decompression procedure, which is designed to relieve intraosseous pressure while also promoting new bone formation and angiogenesis. Some early studies using whole bone marrow transplantation have found a link between the number of osteoprogenitor cells and the outcome. |
CELL TISSUE TECHNOLOGY SDN BHD
Malaysia's FIRST Tissue Engineering Firm |
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