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​INTRODUCTION

Essential Tremor: Essential tremor (ET) is a neurological condition where an individual experiences uncontrollable and involuntary shaking that can affect almost any part of the body including hands, head, voice, arms and legs.
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Comparison of spiral drawing between individual with essential tremor and healthy control



ESSENTIAL TREMOR

Essential tremor is a neurological disorder that causes involuntary shaking or trembling in different parts and sides of the body. 

A theory suggests that the cerebellum, controlling muscle coordination, is not communicating correctly with other parts of the brain.

​The cause of this illness remains unknown however, genetics are strongly suspected as one of the main causes.

SYMPTOMS

  • The voluntary muscles that are consciously moved are affected
  • Nodding of the head if the head is affected
  • If the larynx or voice box is affected, a shaky and quivering voice can be detected
  • A small and rapid tremor
  • Tremor that is worsened by an activity or movement
  • Tremor that stops or lessens when the certain body part affected is at rest
  • Tremor that stops when asleep
  • Tremor that increases as one gets older
  • Most of the time, the hands, head and voice are affected
  • Other parts of the body such as arms and eyelids might also be affected with time

WHAT CAUSES THE DISEASE?

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Summary of the four proposed pathophysiology of essential tremor
Four main pathophysiologies of essential tremor have been proposed: 
  • Exposure to environmental β-carboline alkaloids and the consequent olivocerebellar hyper-excitation 
  • Deficiency in cerebellar GABA  
  • Climbing of fiber synaptic pathology with related cerebellar oscillatory activity 
  • Extra-cerebellar oscillatory activity​
​According to diagram 2, A is the climbing fiber overgrowth and hyperinnervation. 
  • Reduction of GluRδ2 protein in the Purkinje cells causes climbing fiber synaptic pruning deficits, which lead to hypersynchrony and excessive oscillations in Purkinje cells 
  • B is the increased inferior olive automaticity and synchrony 
  • β-carboline alkaloids, such as harmaline, lead to augmented T-type calcium channel function and potentially increased inferior olive synchrony via gap junctions 
  • C and D depicts GABA dysregulation 
  • GABA receptor knockout in Purkinje cells and reduced GABA receptors in the deep cerebellar nucleus can lead to abnormal oscillations in the circuitry

CURRENT TREATMENTS

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Medications and injections currently used to treat essential tremor:
Medication
Function
Limitation
Beta Blockers
Beta blockers such as propranolol help relieve tremors ​
  • ​​Not a good option for individuals with asthma or certain heart problems 
  • Side effects may include fatigue, lightheadedness or heart problems
Anti-Seizures
  • Epilepsy drugs may be effective in individuals who don't respond to beta blockers
  • Other medications that might be prescribed include gabapentin and topiramate​
Side effects include drowsiness and nausea, which usually disappear within a short time
Tranquilizers
Benzodiazepine drugs such as clonazepam may be used to treat individuals whose tension or anxiety worsens tremors ​
  • Side effects can include fatigue or mild sedation
  • Should be used with caution because they can be habit-forming
Botox Injections
  • Might be useful in treating some types of tremors, especially head and voice tremors
  • One injection can improve tremors for up to three months at a time
  • If used to treat hand tremors, it can cause weakness in the fingers 
  • If used to treat voice tremors, it can cause a hoarse voice and difficulty swallowing
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​Nerve stimulation devices:
  • A wearable electronic peripheral nerve stimulation device is a newer form of treatment option for people with essential tremor
  • The device that can be worn works by stimulating peripheral nerves and muscles to create a muscle response that reduces tremors. Studies have found that the device can bring some improvement for tremors
  • Limitations of the new nerve stimulation device is that it takes too long for only small improvements to show
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Surgery:
  • Deep brain stimulation
  • Focused ultrasound thalamotomy
  • Disadvantages of surgeries are the risks of complications and the costly procedures 
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Therapy is also one of the treatment options to treat essential tremor:
  • Physical therapy is where exercises are taught in order to increase muscle strength, coordination and control
  • Occupational therapy provides devices to help an individual with essential tremor adapt and reduce its effects
  • Disadvantages of therapy include only improving the symptoms of essential tremors and not targeting the root of the cause

WHAT WE OFFER?

EXOSOME THERAPY - CELLTIX

​CelltiX is an extracted communicating vesicle derived from Umbilical Cord Derived Mesenchymal Stem Cells (MSCs). CelltiX is prepared in our state-of-the-art cGMP facility.

​CelltiX is a new type of major paracrine factor released by MSCs into a culture medium playing an important function in a multitude of biological processes.
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STEM CELL THERAPY - CELLTIMAX

CelltiMax is Mesenchymal Stem Cells (MSCs) derived from human umbilical cords. Upon treatment, the cultured cells are injected intramuscularly / intravenously into the patient.

​The cells are characterized by low immunogenicity. Hence, it is very safe, tolerable, and free of side effects. It has the capability to differentiate into specialized cells with specific functions for many parts of the body. They can reduce inflammation, repair, renew, regenerate, and replace damaged cells. 
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COMPARISON BETWEEN STEM CELL EXOSOMES 

Criterias
Stem Cells
Exosomes
Definitions
​Stem cells are unspecialized cells of the human body
​Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells
Function
​Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body
Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells
Origins
​Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells
Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized
Growth Factors
​Less amount of growth factors compared to exosomes
​Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells
Administration
  • IV Stem Cell Therapy (Intravenous administration)
  • Intrathecal (directly into the spinal canal)
  • Site injections into problem areas (Knee, hips, hands, etc)
  • Intravenous (IV) therapy
  • Direct injection in the treatment area​

BENEFITS OF OUR TREATMENTS

Stem Cell Therapy
Exosome Therapy
​Improve bodies' natural healing abilities
High stabililty
​Modulate the immune system
Low toxicity and immunogenicity
​Locate and reduce areas of inflammation
High penetration
​Replace damaged and diseased cells
Enhanced delivery efficiency

HOW IT WORKS?

STEM CELL THERAPY (CELLTIMAX)

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How stem cells can help decrease and repair damages caused by neurodegenerative diseases
Previous studies on stem cells have shown that the effects of stem cells on endogenous cells include: 
  • Promotion of functional recovery of nervous tissue, 
  • differentiation into neuronal and glial cells,
  •  Reduction of motor impairments. 
These cells can develop into neural progenitor cells (NPCs) and mesenchymal stem cells (MSCs), from which brain cells of various neuronal and glial lineages, including oligodendrocytes and astrocytes, can be produced.

​

EXOSOME THERAPY (CELLTIX) 

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Illustration of an exosome as well as its characteristic that aid in essential tremor treatment
Exosomes function as tiny messengers that provide vital genetic data, proteins, and messenger RNA to cells throughout our body. They aid in information transmission between cells and improve cell communication.

It has been demonstrated that exosomes from youthful stem cells can rejuvenate older stem cells in our bodies, help control a hyperactive immune system, and modify the immune system so that it works more efficiently and cogently. Because of its anti-inflammatory and immunomodulating properties, exosome treatment has been proven to be helpful for treating essential tremors.

TALK TO US

​If you feel we might be able to offer meaningful improvement to both your condition and your quality of life, then please reach out to schedule a free consultation with one of our in-house clinical experts. We offer consultations in both Malay and English. 

​During your consultation, we will:

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Review your medical history & recent evaluations
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Explore what your treatment package might look like​
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Discuss practical next steps,
​if you feel we can effectively treat you
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Answer any questions you have about the therapies
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Answer any questions you have about us

To schedule your consultation, click the button below

book now
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  • Home
  • About
    • Company
    • Message from CEO
    • Ecosystem >
      • Overview
      • Cell Tissue GMP Laboratory
      • Celllora Clinic >
        • Regenmed by Celllora®
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      • Celllora® MediSpa
      • Celllora® Shop
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        • About
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        • Why Bio-Bank?
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  • Stem Cells
    • Power of Stem Cells
    • As We Age
  • Potentially Treatable Conditions
    • General Wellness
    • Adrenal Cortex >
      • Men's Hormonal Imbalance
      • Women's Hormonal Imbalance
    • Body >
      • Angiogenesis
      • Back Pain
      • Blood Vessel Disease
      • Coma
      • Diabetes Mellitus
      • Immunity Booster
      • Multiple Sclerosis
      • Osteoarthritis
      • Rheumatoid Arthritis
      • Systemic Lupus Erythematosus
      • Whitening
    • Brain >
      • Autism
      • Alzheimer's Disease
      • Hypothalamus Related Condition
      • Pituitary Related Condition
      • Stroke
    • Eye >
      • Corneal Abrasion
      • Diabetic Retinopathy
      • Eye Inflammation
      • Macular Degeneration
      • Retinitis Pigmentosa
    • Genitals >
      • Erectile Dysfunction
      • Premature Ejaculation
      • Prostate Health
      • Vaginal Rejuvenation
    • Hair >
      • Hair Loss & Thinning
    • Heart >
      • Cardiomyopathy
    • Kidneys >
      • Acute / Chronic Kidney Disease
      • Kidney Impairment
    • Liver >
      • Fatty Liver
    • Lungs >
      • Pneumonia / Asthma
      • COVID / Respiratory Problems
    • Muscles / Tendons / Ligaments / Cartilages >
      • Avascular Necrosis
      • Diabetic Foot Ulcer
      • Joint Pain / Injury
      • Muscle Weakness
      • Sports Injury
    • Nervous System >
      • Central Nervous Impairment
      • Essential Tremor
      • Neuronal Damages
      • Neuropathy
      • Parkinson's Disease
      • Spinal Cord Injury
    • Skin >
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    • Medical Use >
      • Shop Now
      • CelltiMax
      • CelltiX Nebulizer
      • CelltiSS
      • CelltiNK
      • MyDerm®
      • CelltiGraft®
      • ALGraft
    • Cosmetic Use >
      • Celllora Cosmeceuticals
    • Research Use
  • Services
    • Programs >
      • Stem Cell Program
      • NK Cell Program
      • Secretome & Exosome Program
      • Advanced Wound Care Program
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  • Projects
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  • Join Us
    • Career
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  • Contact Us