MACULAR DEGENERATION Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a progressive loss of vision in the center of the visual field. In its early stages, there may be no signs of the condition. However, over time, some people may experience a gradual decline in eyesight, which can affect one or both eyes. While it does not lead to total blindness, loss of central vision can make it difficult to perform everyday tasks such as recognizing faces, driving, reading, etc. Visual hallucinations may also occur, but they do not indicate a mental condition.
Macular degeneration is more common in older adults. Risk factors include smoking and genetic factors. It is caused by damage to the retina's macula. A comprehensive eye exam is used to make the diagnosis, and the severity is classified as early, middle, or late. The late stage is further divided into "dry" and "wet" forms, with the dry form accounting for 90% of cases. |
EXOSOME THERAPY - CELLTIX
CelltiX is a type of extracellular vesicle from Umbilical Cord-Derived Mesenchymal Stem Cells (MSCs) manufactured in a cGMP-compliant facility. It is a novel form of a major paracrine factor released by MSCs into a culture medium, which plays an important role in a wide range of biological processes.
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STEM CELL - CELLTIMAX
CelltiMax is a product derived from human umbilical cord-derived Mesenchymal Stem Cells (MSCs). The cells are cultured, then administered to the patient via intramuscular or intravenous injection.
The cells have low immunogenicity making them safe, well-tolerated and free of side effects. They have the ability to differentiate into specialized cells with specific functions for various parts of the body, and can reduce inflammation, repair, renew, regenerate, and replace damaged cells. |
CRITERIAS |
STEM CELLS |
EXOSOMES |
Definition |
Stem cells are unspecialized cells of the human body |
Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells |
Function |
Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body |
Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells |
Origins |
Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells |
Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized |
Growth Factors |
Less amount of growth factors compared to exosomes |
Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells |
Administration |
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Stem Cell Therapy |
Exosome Therapy |
Accelerates healing. |
Reduced inflammation |
Eliminates pain and inflammation |
Supports metabolic function |
Avoids the need for surgery |
Improves brain health |
Enhances collagen production |
Reduces chronic pain |
Decrease nerve damage |
Enhances tissue regeneration |
Less invasive procedure |
Boost immune health |
Mesenchymal Stem Cells (MSCs) have been extensively researched for their potential in treating a variety of retinal diseases. Their therapeutic potential is due to their ability to differentiate into multiple lineages and secrete a variety of immunomodulatory, anti-angiogenic, and neurotrophic factors. Several studies have reported on the role of MSCs in retinal repair and regeneration, with MSC-secreted factors preventing retinal degeneration and improving retinal morphology and function.
MSCs also donate mitochondria to help retinal cells function, and exosomes secreted by MSCs have been shown to have anti-apoptotic and anti-inflammatory properties. Based on promising preclinical results, several clinical trials are being conducted to investigate the potential benefits of MSCs for the treatment of retinal diseases. |
Display Mesenchymal Stem Cells for Treatment of Retinal Diseases
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CELL TISSUE TECHNOLOGY SDN BHD
Malaysia's FIRST Tissue Engineering Firm |
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