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The Poster for "What causes an early climax?"
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It is unknown what causes premature ejaculation. It was previously thought to be purely psychological. However, doctors now understand that premature ejaculation is caused by a complex interaction of psychological and biological factors. Psychological causes
Psychological factors that might play a role include:
Biological causes
Several biological factors might contribute to premature ejaculation. They may include:
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CRITERIAS |
STEM CELLS |
EXOSOMES |
Definition |
Stem cells are unspecialized cells of the human body |
Extracellular vesicles, which is the medical term for tiny bubbles that are released from stem cells |
Function |
Unique, can become any type of cell, and they act as both building blocks and repair mechanisms in your body |
Carry genetic information and proteins to cells throughout your body, and they create paths for communication between cells |
Origins |
Donor stem cells are placed in your body and are guided into becoming specific cells in the body to replace and repair diseased cells |
Exosomes are extracted from donated human mesenchymal stem cells (MSCs) and sterilized |
Growth Factors |
Less amount of growth factors compared to exosomes |
Exosomes contain nearly three times the amount of growth factors. More growth factors mean a better ability to restore and revitalize target cells |
Administration |
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EXOSOME THERAPY |
High stabililty |
Low toxicity and immunogenicity |
High penetration |
Enhanced delivery efficiency |
MSC-derived exosomes ameliorate Premature Ejaculations' in a rat model of cavernous nerve injury
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3D spheroid culturing afforded a 278-fold increase in the total protein content of CM, as compared to that from 2D cultures; the protein concentration increased by 19 times on increasing the centrifugation time for cut-off filtering. Biochemical assays indicated that the CM contains various types of angiogenic, neurotrophic, and anti-inflammatory factors. Histological assay results showed that MSC-CM has angio- and neuro-trophic effect in a CN injury rat model in vivo, and these therapeutic effects appear in a dose-dependent manner.
The experimental results confirmed the therapeutic effect of MSC-CM in healing damaged cavernosal tissue and restoring erectile function. These results successfully demonstrated that MSC-CM has significant potential for the treatment of Premature Ejaculation. |
CELL TISSUE TECHNOLOGY SDN BHD
Malaysia's FIRST Tissue Engineering Firm |
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